Chiara Muti attended the Academy of Dramatic Arts Paolo Grassi in Milan, improving her theatrical studies at the Academy of Piccolo Teatro in Milan, directed by Giorgio Strehler.

Chiara Muti is a theatre and cinema actress ; she made her debut in 1995 as Euridice in Orfeo by Claudio Monteverdi, directed by Micha Van Hoecke. With the Belgian choreographer and director, she created an artistic bond which brought her to be performer and co-author of three new productions which were presented for the first time at the Festival of Ravenna: Pèlerinage in 1997; Salomè in 2008 , based on Oscar Wilde , and Le Baccanti in 2009, based on Euripide.

Her cooperation with the composer Azio Corghi has been fruitful: in 2005 she took part in Pia (from M. Yourcenar ) directed by Valter Malosti at Teatro dell’Opera di Roma; in 2006, she was Zerlina in the opera Il Dissoluto Assolto (from J. Saramago) the world première at Teatro Sao Carlos in Lisboa directed by Andrea De Rosa; in 2009 she was Giocasta ( text by Maddalena Mazzocut-Mis), directed by Riccardo Canessa for Teatro Olimpico in Vicenza , in 2014, she was the voice in Blanquette, in Siena for the 71st edition of the Settimana Musicale Senese.

In 1996 she was Tatiana in Eugen Onegin by Alexander S. Puskin, music by Prokovief, for the Accademia Chigiana in Siena. In 2000 she was Jeanne d’Arc au Bûcher by Arthur Honneger for the Spoleto Festival . In 2007 she was Marie Galante by Kurt Weill directed by Josepoh Rochlitz in Roma for Teatro dell’Opera . She was the voice of Sherazade in the concert/show Le due Lune conducted by Damiano Giuranna for Parco della Musica in Rome as well as at the National Theatre in Alger .

In 2008 she recited the poems by Dante Alighieri in Dante Symphonie by Franz Liszt conducted by Vittorio Bresciani for the Sagra Musicale Umbra in Perugia , performed again at the Budapest Festival 2015 . She is Elia,music by Giovanni Tamborrino , at the Cathedral in Bari. In 2008 she played in Passiuni by G. Sollima with the Orchestra Giovanile Luigi Cherubini conducted by Riccardo Muti for the Ravenna Festival . In 2009 she is interpreter of Le Martyre de Saint Sébastien by Debussy and Gabriele D’Annunzio with Orchestra National de Montpellier conducted by Alain Altinouglou.

Since 2002 she has collaborated with the writer and director Ruggero Cappuccio for whom she was the leading actress in Orlando Furioso by Ludovico Ariosto, then in 2008 she took part in Desideri Mortali for Teatro Massimo in Palermo and, in 2010, she was the voice of Natura Viva, music by Marco Betta for Maggio Musicale Fiorentino.

Since 1995, she has had an intense activity in comedies and dramas: she made her début with La Madre Confidente by Marivaux, role of Angélique, directed by Franco Però. In 1996 she took part in Liliom by Ferenc Molnar, directed by Gigi Dall’Aglio and in Medea by Euripides directed by Marco Bernardi. In 1997 she is Iphigenia in Le Erinni by Quintavalle and in 1998 she is Lady Macbeth in Macbeth Clan directed by Angelo Longoni for the Piccolo Teatro in Milano. In 2001 she is the stepdaughter in I sei personaggi in cerca d’autore by Luigi Pirandello, directed by Maurizio Scaparro. In 2004 she is Francesca da Rimini and in 2005 she is Teresa Guiccioli in Ridono i sassi ancor della città, directed by Elena Bucci. From 2004 until 2006 she was Antigone in Antigone by Sophocles by Bertolt Brecht with Sandro Lombardi, directed by Federico Tiezzi.

Her activity in the movies world is intense. She played in Rosa e Cornelia by Giorgio Treves, La Via degli Angeli by Pupi Avati, Il Partigiano Johnny by Guido Chiesa and Musikanten by Franco Battiato.

Chiara Muti in 1996 was awarded with Premio Anna Magnani and in 1997 with Premio Eleonora Duse by the Italian theatre critics as best young italian actress. In 1999 she was awarded with La Grolla d’Oro as best actress for the film Rosa e Cornelia.

As director she makes her debut in 2007 with two productions in which she appears both as actress and director: Il Regno di Rucken for Teatro Comunale di Salerno and Il Sogno di Ludwig for Ravello Festival. In 2010 she puts up Cardo Rosso, by Maddalena Mazzocut-Mis , music by Giovanni Sollima.

In 2012 she made her debut as stage director with Sancta Susanna by Hindemith, conducted by Riccardo Muti, for Ravenna Festival. In 2013 she has been invited by Teatro dell’Opera of Roma for a new production of Dido and Aeneas by Purcell, and again in 2014 for Manon Lescaut by Puccini. Orfeo ed Euridice by Gluck is the opera she directed for the Opéra National de Montpellier and in 2014 Manon Lescaut by Puccini at the Teatro dell’Opera in Rome. In 2016 she has been invited to open the Teatro Petruzzelli’s Opera Season in Bari with Le Nozze di Figaro by W.A. Mozart.